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XDeepCell - Research project
Explainable deep models in cell imaging: application to the analysis of structural changes in human cells for diagnostic purpose
PhD student: Martin BLANCHARD, ED 488 SIS (Science, Engineering, Health)
ABSTRACT
The biological function of a cell is very often associated with its morphology. For example, in the case of human podocytes (cells involved in renal glomerular filtration), the morphological modifications observed on in vitro cultures are associated with a modification of the permeability and allow to quantify the toxicity level of a drug. This project proposes to jointly address first a problem of morphological characterization from biology and second a computer vision problem based on advanced deep learning methods. On the biology side, the aim is to understand the structural modifications of cells after treatment (known drugs or biological samples of interest) and to propose a method of statistical quantitative characterization allowing to evaluate the degree of functional damage linked to the toxicity or to the considered pathology. In terms of computer vision, the aim is to propose explainable models for representation learning in a context of poorly annotated data. Indeed, in the context of the toxicity study, we have access to a global annotation of the image while the cells are not systematically all affected by the treatment.
About the XDeepCell project
RESEARCH AXIS
Axis #2
KEYWORDS
Computer vision, deep learning, explicability, representation learning, morphology, cell structure, structure-function relationship, therapeutic drug screening.
DURATION - STATUS
01/10/2022 – 30/09/2025 - Ongoing
PhD STUDENT
Martin BLANCHARD
PROJECT COORDINATORS
Christophe DUCOTTET (LabHC)
COORDINATING LABORATORY
Hubert Curien Laboratory (LabHC)
PARTNER LABORATORIES - OTHER PARTNERS
SAINBIOSE Laboratory
PARTNER RESEARCHERS
Olivier DELÉZAY (SAINBIOSE)
Damien MUSELET (LabHC)
Axis #2
KEYWORDS
Computer vision, deep learning, explicability, representation learning, morphology, cell structure, structure-function relationship, therapeutic drug screening.
DURATION - STATUS
01/10/2022 – 30/09/2025 - Ongoing
PhD STUDENT
Martin BLANCHARD
PROJECT COORDINATORS
Christophe DUCOTTET (LabHC)
COORDINATING LABORATORY
Hubert Curien Laboratory (LabHC)
PARTNER LABORATORIES - OTHER PARTNERS
SAINBIOSE Laboratory
PARTNER RESEARCHERS
Olivier DELÉZAY (SAINBIOSE)
Damien MUSELET (LabHC)