SAINBIOSE Laboratory

SAINBIOSE is a multi/interdisciplinary and translational laboratory combining expertise in biology, bioengineering, biomechanics, numerical modelling and clinical research. The methodological and technical contributions, including complex modelling, imaging (tissue/cell, rodent, human), high-resolution spectrometry, preclinical in vitro and in vivo and in silico models, are unique and cutting-edge.
The laboratory's research aim at understanding the regulatory processes involved in osteo-articular (LBTO Team) or cardiovascular (DVH Team) biostress situations, at developing dynamic models to reproduce these processes and at developing technological innovations. The objective is to propose a precision medicine during aging and for specific populations (astronauts, newborns, pregnant women, very old subjects...).
The laboratory is a joint research unit involving 170 researchers coming from the INSERM, the Faculty of Medicine, the Health Engineering Center (Ecole des Mines de St-Etienne), the university hospital (CHU), the Centre d’Investigation Clinique (CIC), and the Scientific Department of Etablissement Français du Sang (EFS) Auvergne Rhône-Alpes.



The SAINBIOSE lab, with its two teams working on osteo-articular and cardio-vascular problematics, implement research projects in collaboration with high-level international partners:
  • Life-sciences space-related collaborations with the European Space Agency – ESA (France), the Centre National d’Études Spatiales – CNES (France), the Russian space agency – Roscosmos (Russia), the Italian Space Agency - ASI (Italy), the UK Space Agency – UKSA (UK), the German Aerospace Centre (Germany), Portugal Space– PSA (Portugal), the Canadian Space Agency – CSA (Canada), the National Aeronautics and Space Administration - NASA (USA).
  • Laser-induced hierarchical micro-/nano-structures for controlled cell adhesion at implants (LaserImplants), in partnership with Universitat Linz – JKU (Austria), Bundesanatalt fuer materialforschung und-prefung – BAM (Germany), Danube private university GMBH – DPU (Austria), HOFER GMBH & CO KG (Austria).
The lab is also involved in Research networks (the COST network, the SPECTRA group (HR-pQCT, H. Marotte), the INVENT-VTE network, including innoVTE) and participates in international clinical studies: PRONOMOS (NCT02401594, 11 countries, Bayer Laboratory), HIGHLOW (NCT01828697).


The Osteo-Articular Tissue Biology Laboratory - LBTO team's research focuses on the mechanisms of bone loss in situations of reduced mechanical stress (sedentary lifestyle, effect of age, accelerated aging), on bone repair and inflammatory joint pathologies.


The team works towards:
  • the manufacture of biomaterials for bone applications (e.g., custom-made culture media and implants, regeneration of large bone defects)
  • the development of in vitro bone tissue models
  • the understanding of the behavior and aging of orthopedic implants
  • the study and improvement of material surfaces and surface treatments to extend implants’ life.
The LBTO team maintains its international leadership in the field of space research with a multi-scale approach, but also on Sibling’s proteins, tribo-corrosion of orthopaedic implants, bone vascularisation and bone substitutes. Two emerging themes - osteo-immunology and the effects of mother-of-pearl on bone tissue - are integrated into both the team's strategy and the local environment.

The team also develops new approcahes to high-level projects with the objectives of:
  1. Understanding bone and joint mechanotransduction during modified mechanical stimuli (e.g. gravity vector) considering material-tissue interactions; developing bioinstructive materials for the understanding of the cell-material interaction mechanisms, and the development of musculoskeletal tissues repair and regenerative solutions.
  2. Developing new super-resolution methods (ie. Machine Learning) to enhance the quality of conventional clinical X-Ray scans images to better explore the 3D architecture and porosities of bone. The learned model will lead to the clinical prediction of bone porosities in osteoporotic patients and cosmonauts.

  • Klos, A.; Sedao, X.; Itina, T.E.; Helfenstein-Didier, C.; Donnet, C.; Peyroche, S.; Vico, L.; Guignandon, A.; Dumas, V. Ultrafast Laser Processing of Nanostructured Patterns for the Control of Cell Adhesion and Migration on Titanium Alloy. Nanomaterials 2020, 10, 864.
  • Bouet G, Cabanettes F, Bidron G, Guignandon A, Peyroche S, Bertrand P, Vico L, Dumas V. Laser-Based Hybrid Manufacturing of Endosseous Implants: Optimized Titanium Surfaces for Enhancing Osteogenic Differentiation of Human Mesenchymal Stem Cells. ACS Biomater Sci Eng. 2019 Sep 9;5(9):4376-4385. doi: 10.1021/acsbiomaterials.9b00769.
  • Juignet, L.; Charbonnier, B.; Dumas, V.; Bouleftour, W.; Thomas, M.; Laurent, C.; Vico, L.; Douard, N. et al. (2017). Macrotopographic closure promotes tissue growth and osteogenesis in vitro. ACTA BIOMATERIALIA. 53 : 536 - 548. doi: 10.1016/j.actbio.2017.02.037
  • Dumas, V.; Guignandon, A.; Vico, L.; Mauclair, C.; Zapata, X.; Linossier, M. T.; Bouleftour, W.; Granier,J. et al. (2015). Femtosecond laser nano/micro patterning of titanium influences mesenchymal stemcell adhesion and commitment. BIOMEDICAL MATERIALS. 10 (5) : - . doi: 10.1088/1748-6041/10/5/055002
  • Vico, L.; van bert Rietbergen, B.; Vilayphiou, N.; Linossier, M.; Locrelle, H.; Normand, M.; Zouch, M.; Gerbaix, M. et al. (2017). Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions. J BONE MINER RES.. 32(10) (10) : 2010-2021. doi: 10.1002/jbmr.3188.