Laurence VICO

Laurence Vico's research on the skeletal system encompasses the understanding of the mechanical and metabolic deconditioning occurring in extreme (spaceflight and analogs) or disuse (osteoporosis, inactivity) conditions. Such (dys)adaptations include intertwined loops leading to bone loss. Other targets are the effects of pharmaceutical and physical training strategies and their safe and efficient application to frail subjects.

  • Head of INSERM Unit 1059 with 2 teams (Osteo-articular biology and dysfunctions of vascular and homeostasis functions)
  • Coordination of international projects related to space field with the French National Centre for Space Studies (CNES); with the European space agency (ESA) (ex: Microgravity Application Programs, since 2009 with 10 groups in Europe; Human skeletal adaptation to spaceflights “EDOS”, since 2014).
  • Board of Medes (Institute of Space Medicine and Physiology in Toulouse, France), member of various committees (ex. CNES-INSERM, ESA's Life Science Working Group…), Editorial Board of Frontiers (2014-2019) and Calcified Tissue Int (2014-).

  • Visiting Senior Lecturer at Kings College London pour le King’s Master's in Space Physiology & Health

  • INSERM School and Fondation Liliane Bettencourt Schueller, Thematic days, 15-17 March, 2019
  • Bone Academy meeting, Berlin 19-21 nov 2010 : The physiological role of bone remodelling

  • Klos A, Sedao X, Itina TE, Helfenstein-Didier C, Donnet C, Peyroche S, Vico L, Guignandon A, Dumas V. Ultrafast Laser Processing of Nanostructured Patterns for the Control of Cell Adhesion and Migration on Titanium Alloy. Nanomaterials (Basel). 2020;10(5):E864. Published 2020 Apr 30. doi:10.3390/nano10050864
  • Vico L, Hargens A. Skeletal changes during and after spaceflight. Nat Rev Rheumatol. 2018 Mar 21;14(4):229-245. doi: 10.1038/nrrheum.2018.37. Review. PubMed PMID: 29559713.
  • Juignet L, Charbonnier B, Dumas V, Bouleftour W, Thomas M, Laurent C, Vico L, Douard N, Marchat D, Malaval L. Macrotopographic closure promotes tissue growth and osteogenesis in vitro. Acta Biomater. 2017;53:536-548. doi:10.1016/j.actbio.2017.02.037.
  • Bouet G, Marchat D, Cruel M, Malaval L, Vico L. In vitro three-dimensional bone tissue models: from cells to controlled and dynamic environment. Tissue Eng Part B Rev. 2015 Feb;21(1):133-56. doi: 10.1089/ten.TEB.2013.0682. Epub 2014 Sep 26. Review. PubMed PMID: 25116032.
  • Dumas V, Rattner A, Vico L, Audouard E, Dumas JC, Naisson P, Bertrand P. Multiscale grooved titanium processed with femtosecond laser influences mesenchymal stem cell morphology, adhesion, and matrix organization. J Biomed Mater Res A. 2012;100(11):3108-3116. 3