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QUMIN - Research project
Quantitative in situ imaging and machine learning of cell/matrix mechanical interactions for cell biology
Post-doctoral fellow: Chloé TECHENS
ABSTRACT
It is now well established in biology that the cellular response and phenotype are determined by the local mechanical environment at the cellular level. This means that there should be a direct correlation between the local biological function of each cell and the local mechanical properties of the surrounding microenvironment. However, this correlation has never been characterized until now. Therefore, our main goal is to map the mechanical stimuli around vascular smooth muscle cells in collagen hydrogels, including strain gradients, strains and stresses, and correlate them to specific local phenotypic parameters. For this, we propose to engrave micro-markers around cells in collagen hydrogels by densification thanks to the femtosecond laser, then to precisely follow the position of these markers in confocal microscopy at first (microscopic resolution), then in-line holography in a second step (nanometric resolution). These precise and real-time measurements will be employed to develop a machine learning model of the mechanical interactions between the cell and its environment, with major potential applications for the diagnosis of cancers or cardiovascular diseases.
ABOUT the NANOTRAP project
RESEARCH AXES
Axis #2
KEYWORDS
Mechanobiology, in-line holography,
vascular smooth muscle cell, collagen hydrogel,
densification using femtosecond laser
DURATION - STATUS
01/10/2023 – 31/03/2025 - To be started
POST-DOCTORAL FELLOW
Chloé TECHENS (SAINBIOSE)
PROJECT COORDINATOR
Stéphane AVRIL (SAINBIOSE)
COORDINATING LABORATORY
SAINBIOSE lab
PARTNER LABORATORIES
Georges Friedel lab (LGF)
Hubert Curien lab (LabHC)
DCAC - Défaillance Cardiovasculaire Aiguë
et Chronique (U1116 Inserm, Université de Lorraine)
Yale University (CT, USA)
PARTNER RESEARCHERS
David EGLIN (SAINBIOSE)
Jérôme MOLIMARD (SAINBIOSE)
Chloé TECHENS (SAINBIOSE)
Alain GUIGNANDON (SAINBIOSE)
Thomas OLIVIER (LabHC)
Corinne FOURNIER (LabHC)
Vincent BARNIER (LGF)
Patrick LACOLLEY (DCAC)
Jay HUMPHREY (YaleU)
Axis #2
KEYWORDS
Mechanobiology, in-line holography,
vascular smooth muscle cell, collagen hydrogel,
densification using femtosecond laser
DURATION - STATUS
01/10/2023 – 31/03/2025 - To be started
POST-DOCTORAL FELLOW
Chloé TECHENS (SAINBIOSE)
PROJECT COORDINATOR
Stéphane AVRIL (SAINBIOSE)
COORDINATING LABORATORY
SAINBIOSE lab
PARTNER LABORATORIES
Georges Friedel lab (LGF)
Hubert Curien lab (LabHC)
DCAC - Défaillance Cardiovasculaire Aiguë
et Chronique (U1116 Inserm, Université de Lorraine)
Yale University (CT, USA)
PARTNER RESEARCHERS
David EGLIN (SAINBIOSE)
Jérôme MOLIMARD (SAINBIOSE)
Chloé TECHENS (SAINBIOSE)
Alain GUIGNANDON (SAINBIOSE)
Thomas OLIVIER (LabHC)
Corinne FOURNIER (LabHC)
Vincent BARNIER (LGF)
Patrick LACOLLEY (DCAC)
Jay HUMPHREY (YaleU)